Structure function relationships in the lymphatic system and implications for cancer biology.
Identifieur interne : 007841 ( Main/Exploration ); précédent : 007840; suivant : 007842Structure function relationships in the lymphatic system and implications for cancer biology.
Auteurs : Marlys H. Witte [États-Unis] ; Kimberly Jones ; Jörg Wilting ; Michael Dictor ; Manuel Selg ; Noel Mchale ; Jeffrey E. Gershenwald ; David G. JacksonSource :
- Cancer metastasis reviews [ 0167-7659 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Cellules endothéliales (physiologie), Humains, Lymphangiogenèse (génétique), Lymphoedème (génétique), Lymphoedème (physiopathologie), Métastase lymphatique, Noeuds lymphatiques (physiologie), Néovascularisation pathologique, Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie), Système lymphatique (anatomie et histologie), Système lymphatique (embryologie), Système lymphatique (immunologie), Système lymphatique (physiologie), Tumeurs (), Tumeurs (anatomopathologie), Tumeurs (physiopathologie), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (physiologie).
- MESH :
- anatomie et histologie : Système lymphatique.
- anatomopathologie : Tumeurs, Vaisseaux lymphatiques.
- embryologie : Système lymphatique.
- génétique : Lymphangiogenèse, Lymphoedème.
- immunologie : Système lymphatique.
- physiologie : Cellules endothéliales, Noeuds lymphatiques, Récepteur-3 au facteur croissance endothéliale vasculaire, Système lymphatique, Vaisseaux lymphatiques.
- physiopathologie : Lymphoedème, Tumeurs.
- Animaux, Humains, Métastase lymphatique, Néovascularisation pathologique, Tumeurs.
English descriptors
- KwdEn :
- Animals, Endothelial Cells (physiology), Humans, Lymph Nodes (physiology), Lymphangiogenesis (genetics), Lymphatic Metastasis, Lymphatic System (anatomy & histology), Lymphatic System (embryology), Lymphatic System (immunology), Lymphatic System (physiology), Lymphatic Vessels (pathology), Lymphatic Vessels (physiology), Lymphedema (genetics), Lymphedema (physiopathology), Neoplasms (pathology), Neoplasms (physiopathology), Neoplasms (therapy), Neovascularization, Pathologic, Vascular Endothelial Growth Factor Receptor-3 (physiology).
- MESH :
- chemical , physiology : Vascular Endothelial Growth Factor Receptor-3.
- anatomy & histology : Lymphatic System.
- embryology : Lymphatic System.
- genetics : Lymphangiogenesis, Lymphedema.
- immunology : Lymphatic System.
- pathology : Lymphatic Vessels, Neoplasms.
- physiology : Endothelial Cells, Lymph Nodes, Lymphatic System, Lymphatic Vessels.
- physiopathology : Lymphedema, Neoplasms.
- therapy : Neoplasms.
- Animals, Humans, Lymphatic Metastasis, Neovascularization, Pathologic.
Abstract
The lymphatic system, composed of lymphatic vessels, lymph, lymph nodes, and lymphocytes, is a distinctive vasculature (discontinuous basement membrane, open endothelial junctions, anchoring filaments, valves, and intrinsic contractility), different yet similar to the blood vasculature; an integral component of the plasma-tissue fluid-lymph circulation (the "blood-lymph loop"); and the center of the immunoregulatory network. Lymphatics are involved in diverse developmental, growth, repair, and pathologic processes both analogous to and distinct from those affecting the blood vasculature. Interference with the blood-lymph loop produces swelling [an imbalance between lymph formation (regulated by Starling's law of transcapillary fluid exchange) and lymph absorption], scarring, nutritional and immunodysregulatory disorders, as well as disturbances in lymph(hem)angiogenesis (lymphedema-angiodysplasia syndromes). The lymphatic system is also the stage on which key events during cancer development and progression are played out, and historically, also forms the basis for current evaluation, prognostication, and/or both operative and non-operative treatment of most cancers. Recent advances in molecular lymphology (e.g., discovery of lymphatic growth factors, endothelial receptors, transcription factors, genes, and highly specific immunohistochemical markers) and growing interest in lymphangiogenesis, combined with fresh insights and refined tools in clinical lymphology, including non-invasive lymphatic imaging, are opening up a window for translation to the clinical arena. Therefore, in cancer biology, attention to the multifaceted structure-function relationships within this vast, relatively unexplored system is long overdue.
DOI: 10.1007/s10555-006-8496-2
PubMed: 16770531
Affiliations:
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Witte</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Arizona, Tucson, AZ, USA. lymph@u.arizona.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Arizona, Tucson, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Jones, Kimberly" sort="Jones, Kimberly" uniqKey="Jones K" first="Kimberly" last="Jones">Kimberly Jones</name></author><author><name sortKey="Wilting, Jorg" sort="Wilting, Jorg" uniqKey="Wilting J" first="Jörg" last="Wilting">Jörg Wilting</name></author><author><name sortKey="Dictor, Michael" sort="Dictor, Michael" uniqKey="Dictor M" first="Michael" last="Dictor">Michael Dictor</name></author><author><name sortKey="Selg, Manuel" sort="Selg, Manuel" uniqKey="Selg M" first="Manuel" last="Selg">Manuel Selg</name></author><author><name sortKey="Mchale, Noel" sort="Mchale, Noel" uniqKey="Mchale N" first="Noel" last="Mchale">Noel Mchale</name></author><author><name sortKey="Gershenwald, Jeffrey E" sort="Gershenwald, Jeffrey E" uniqKey="Gershenwald J" first="Jeffrey E" last="Gershenwald">Jeffrey E. 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Witte</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Arizona, Tucson, AZ, USA. lymph@u.arizona.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Arizona, Tucson, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Jones, Kimberly" sort="Jones, Kimberly" uniqKey="Jones K" first="Kimberly" last="Jones">Kimberly Jones</name></author><author><name sortKey="Wilting, Jorg" sort="Wilting, Jorg" uniqKey="Wilting J" first="Jörg" last="Wilting">Jörg Wilting</name></author><author><name sortKey="Dictor, Michael" sort="Dictor, Michael" uniqKey="Dictor M" first="Michael" last="Dictor">Michael Dictor</name></author><author><name sortKey="Selg, Manuel" sort="Selg, Manuel" uniqKey="Selg M" first="Manuel" last="Selg">Manuel Selg</name></author><author><name sortKey="Mchale, Noel" sort="Mchale, Noel" uniqKey="Mchale N" first="Noel" last="Mchale">Noel Mchale</name></author><author><name sortKey="Gershenwald, Jeffrey E" sort="Gershenwald, Jeffrey E" uniqKey="Gershenwald J" first="Jeffrey E" last="Gershenwald">Jeffrey E. Gershenwald</name></author><author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G" last="Jackson">David G. Jackson</name></author></analytic><series><title level="j">Cancer metastasis reviews</title><idno type="ISSN">0167-7659</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Endothelial Cells (physiology)</term><term>Humans</term><term>Lymph Nodes (physiology)</term><term>Lymphangiogenesis (genetics)</term><term>Lymphatic Metastasis</term><term>Lymphatic System (anatomy & histology)</term><term>Lymphatic System (embryology)</term><term>Lymphatic System (immunology)</term><term>Lymphatic System (physiology)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphatic Vessels (physiology)</term><term>Lymphedema (genetics)</term><term>Lymphedema (physiopathology)</term><term>Neoplasms (pathology)</term><term>Neoplasms (physiopathology)</term><term>Neoplasms (therapy)</term><term>Neovascularization, Pathologic</term><term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules endothéliales (physiologie)</term><term>Humains</term><term>Lymphangiogenèse (génétique)</term><term>Lymphoedème (génétique)</term><term>Lymphoedème (physiopathologie)</term><term>Métastase lymphatique</term><term>Noeuds lymphatiques (physiologie)</term><term>Néovascularisation pathologique</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie)</term><term>Système lymphatique (anatomie et histologie)</term><term>Système lymphatique (embryologie)</term><term>Système lymphatique (immunologie)</term><term>Système lymphatique (physiologie)</term><term>Tumeurs ()</term><term>Tumeurs (anatomopathologie)</term><term>Tumeurs (physiopathologie)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Lymphangiogenèse</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules endothéliales</term><term>Noeuds lymphatiques</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelial Cells</term><term>Lymph Nodes</term><term>Lymphatic System</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Neovascularization, Pathologic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Métastase lymphatique</term><term>Néovascularisation pathologique</term><term>Tumeurs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic system, composed of lymphatic vessels, lymph, lymph nodes, and lymphocytes, is a distinctive vasculature (discontinuous basement membrane, open endothelial junctions, anchoring filaments, valves, and intrinsic contractility), different yet similar to the blood vasculature; an integral component of the plasma-tissue fluid-lymph circulation (the "blood-lymph loop"); and the center of the immunoregulatory network. Lymphatics are involved in diverse developmental, growth, repair, and pathologic processes both analogous to and distinct from those affecting the blood vasculature. Interference with the blood-lymph loop produces swelling [an imbalance between lymph formation (regulated by Starling's law of transcapillary fluid exchange) and lymph absorption], scarring, nutritional and immunodysregulatory disorders, as well as disturbances in lymph(hem)angiogenesis (lymphedema-angiodysplasia syndromes). The lymphatic system is also the stage on which key events during cancer development and progression are played out, and historically, also forms the basis for current evaluation, prognostication, and/or both operative and non-operative treatment of most cancers. Recent advances in molecular lymphology (e.g., discovery of lymphatic growth factors, endothelial receptors, transcription factors, genes, and highly specific immunohistochemical markers) and growing interest in lymphangiogenesis, combined with fresh insights and refined tools in clinical lymphology, including non-invasive lymphatic imaging, are opening up a window for translation to the clinical arena. Therefore, in cancer biology, attention to the multifaceted structure-function relationships within this vast, relatively unexplored system is long overdue.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li></region></list><tree><noCountry><name sortKey="Dictor, Michael" sort="Dictor, Michael" uniqKey="Dictor M" first="Michael" last="Dictor">Michael Dictor</name><name sortKey="Gershenwald, Jeffrey E" sort="Gershenwald, Jeffrey E" uniqKey="Gershenwald J" first="Jeffrey E" last="Gershenwald">Jeffrey E. Gershenwald</name><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G" last="Jackson">David G. Jackson</name><name sortKey="Jones, Kimberly" sort="Jones, Kimberly" uniqKey="Jones K" first="Kimberly" last="Jones">Kimberly Jones</name><name sortKey="Mchale, Noel" sort="Mchale, Noel" uniqKey="Mchale N" first="Noel" last="Mchale">Noel Mchale</name><name sortKey="Selg, Manuel" sort="Selg, Manuel" uniqKey="Selg M" first="Manuel" last="Selg">Manuel Selg</name><name sortKey="Wilting, Jorg" sort="Wilting, Jorg" uniqKey="Wilting J" first="Jörg" last="Wilting">Jörg Wilting</name></noCountry><country name="États-Unis"><region name="Arizona"><name sortKey="Witte, Marlys H" sort="Witte, Marlys H" uniqKey="Witte M" first="Marlys H" last="Witte">Marlys H. Witte</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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